A core challenge in biomedical and life science research is to decipher cell-to-cell
differences under pathological progression or external perturbation. Microfluidics-based …

A surge of research in intracellular delivery technologies is underway with the increased
innovations in cell‐based therapies and cell reprogramming. Particularly, physical cell …

Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …

In the past few years, messenger RNA (mRNA) has emerged as a promising therapeutic
agent for the treatment and prevention of various diseases. Clinically, mRNA-based drugs …

Nanoparticle-mediated photoporation has arisen as a universal intracellular delivery tool;
however, the direct interaction of nanoparticles and cells hampers its clinical translation …

Human adipose‐derived stem cells (hASCs) are cryopreserved traditionally using dimethyl
sulfoxide (DMSO) as the cryoprotectant agent. DMSO penetrates cell membranes and …

Blebs, spherical membrane bulges of the cell membrane, are ubiquitous structures observed
in various biological phenomena, including apoptosis, cell division, to bleb-based cell …

Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

Brief pulses of electric field (electroporation) and/or tensile stress (mechanoporation) have
been used to reversibly permeabilize the plasma membrane of mammalian cells and deliver …

Cell membrane composed of lipid bilayer is a selectively permeable membrane that only
allows specific molecules to pass through. While such selectivity is essential for the survival …