Precision electronic medicine in the brain

SR Patel, CM Lieber - Nature biotechnology, 2019 - nature.com
Periodically throughout history developments from adjacent fields of science and technology
reach a tipping point where together they produce unparalleled advances, such as the Allen …

Deep brain stimulation: emerging tools for simulation, data analysis, and visualization

K Wårdell, T Nordin, D Vogel, P Zsigmond… - Frontiers in …, 2022 - frontiersin.org
Deep brain stimulation (DBS) is a well-established neurosurgical procedure for movement
disorders that is also being explored for treatment-resistant psychiatric conditions. This …

Directional DBS increases side‐effect thresholds—a prospective, double‐blind trial

TA Dembek, P Reker, V Visser‐Vandewalle… - Movement …, 2017 - Wiley Online Library
Objective The objective of this study was to investigate whether directional deep brain
stimulation (DBS) of the subthalamic nucleus in Parkinson's disease (PD) offers increased …

Predicting irreversible electroporation-induced tissue damage by means of magnetic resonance electrical impedance tomography

M Kranjc, S Kranjc, F Bajd, G Serša, I Serša… - Scientific reports, 2017 - nature.com
Irreversible electroporation (IRE) is gaining importance in routine clinical practice for
nonthermal ablation of solid tumors. For its success, it is extremely important that the …

[HTML][HTML] Anatomical brain structures normalization for deep brain stimulation in movement disorders

D Vogel, A Shah, J Coste, JJ Lemaire, K Wårdell… - NeuroImage: Clinical, 2020 - Elsevier
Deep brain stimulation (DBS) therapy requires extensive patient-specific planning prior to
implantation to achieve optimal clinical outcomes. Collective analysis of patient's brain …

Current practice and the future of deep brain stimulation therapy in Parkinson's disease

L Almeida, W Deeb, C Spears, E Opri… - Seminars in …, 2017 - thieme-connect.com
Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients
experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently …

Biomarkers and neuromodulation techniques in substance use disorders

B Habelt, M Arvaneh, N Bernhardt, I Minev - Bioelectronic medicine, 2020 - Springer
Addictive disorders are a severe health concern. Conventional therapies have just moderate
success and the probability of relapse after treatment remains high. Brain stimulation …

[HTML][HTML] Deep brain stimulation of caudal zona incerta for Parkinson's disease: one-year follow-up and electric field simulations

RS Persson, T Nordin, GM Hariz, K Wårdell… - … : Technology at the …, 2022 - Elsevier
Objective To evaluate the effects of bilateral caudal zona incerta (cZi) deep brain stimulation
(DBS) for Parkinson's disease (PD) one year after surgery and to create anatomical …

Bio-heat model of kilohertz-frequency deep brain stimulation increases brain tissue temperature

N Khadka, IE Harmsen, AM Lozano… - … : Technology at the Neural …, 2020 - Elsevier
Objectives Early clinical trials suggest that deep brain stimulation at kilohertz frequencies
(10 kHz-DBS) may be effective in improving motor symptoms in patients with movement …

Patient-specific simulations of deep brain stimulation electric field with aid of in-house software ELMA

JD Johansson, F Alonso… - 2019 41st annual …, 2019 - ieeexplore.ieee.org
Deep brain stimulation (DBS) is an established technique for reduction of symptoms in
movement disorders. Finite element method (FEM) simulations of the electric field …