As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …