The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

Highly conserved α-and β-tubulin heterodimers assemble into dynamic microtubules and
perform multiple important cellular functions such as structural support, pathway for transport …

Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

Ceramide kinase (CERK) is the mammalian lipid kinase from which the bioactive
sphingolipid, ceramide-1-phosphate (C1P), is derived. CERK has been implicated in several …

Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …

Simple Summary Mitochondria are well known for being the powerhouses of the cell—
whether the cell is normal or cancerous. Moreover, they can move, split, fuse themselves, or …

Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle
bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology …

Research conducted over the last 50 yr has provided insight into the mechanisms by which
insulin stimulates glucose transport across the skeletal muscle cell membrane Transport …