Research of a past decade and a half leaves no doubt that complete understanding of
protein functionality requires close consideration of the fact that many functional proteins do …

Although it is one of the most studied proteins, p53 continues to be an enigma. This protein
has numerous biological functions, possesses intrinsically disordered regions crucial for its …

Structural dynamics of water and its hydrogen-bonding networks play an important role in
enzyme function via the transport of protons, ions, and substrates. To gain insights into these …

Recent experiments, advances in theory, and analogies to other complex systems such as
glasses and spin glasses yield insight into protein dynamics. The basis of the understanding …

We present the development of a force field for simulation of nucleic acids and proteins. Our
approach began by obtaining equilibrium bond lengths and angles from microwave, neutron …

Structural fluctuations in proteins on the picosecond timescale have been studied in
considerable detail by theoretical methods such as molecular dynamics simulation1, 2, but …

A normal mode analysis making use of an empirical potential function including local and
nonlocal (nonbonded) interactions is performed for the bovine pancreatic trypsin inhibitor in …

Volume is a fundamental physical property of molecules that is important in understanding
their structure, function, and interactions. Present methods for computing volumes of …

Gregory A. Petsko Rosenstiel Basic Medical Sciences Research Center, BrandeisUniversity,
Waltham, Massachusetts 02254-9110 Received January 15, 1991; Revised Manuscript …

Presenting a wide-ranging view of current developments in protein research, the papers in
this collection, each written by highly regarded experts in the field, examine various aspects …