Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Aging impairs the integrated immunometabolic responses, which have evolved to maintain
core body temperature in homeotherms to survive cold stress, infections, and dietary …

Systematic characterizations of adipose regulatory T (Treg) cell subsets and their
phenotypes remain uncommon. Using single-cell ATAC-sequencing and paired single-cell …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a
dynamic inflammatory microenvironment consisting of a complex network formed by the …

Objective Psoriasis and multiple sclerosis (MS) are complex immune diseases that are
mediated by T cells and share multiple comorbidities. Previous studies have suggested …

Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …

Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in
suppressing the immune response and maintaining immune homeostasis. After maturation …