The definition of sepsis continues to be as dynamic as the management strategies used to
treat this. Sepsis-3 has replaced the earlier systemic inflammatory response syndrome …

Management of abdominal sepsis requires a multidisciplinary approach. Closing the
abdomen permanently after source control and only reopening it in case of deterioration of …

Background: The Surgical Infection Society (SIS) published evidence-based guidelines for
the management of intra-abdominal infection (IAI) in 1992, 2002, 2010, and 2017. Here, we …

The optimal duration of antibiotic therapy depends on many factors, but overall, many
infections in the critically ill can be treated with short-course antibiotic therapy (7 days or …

Intra-abdominal infections (IAIs) are a common cause of sepsis, and frequently occur in
intensive care unit (ICU) patients. IAIs include many diagnoses, including peritonitis …

Introduction: Intra-abdominal infections remain a leading cause of death, morbidity and
resource use in surgical wards and intensive care units. The growing complexity of their …

Background: After publication of the Study to Optimize Peritoneal Infection Therapy (STOP
IT) trial, we sought to determine if we were implementing study findings into practice …

BACKGROUND Recent studies have evaluated outcomes associated with duration of
antimicrobial treatment for complicated intra-abdominal infections (cIAI). The goal of this …

Complicated intra-abdominal infections (cIAIs) are common and confer significant morbidity,
mortality and costs. In this era of evolving antimicrobial resistance, selection of appropriate …

Introduction The 2017 surgical infection society (SIS) guidelines recommend 4 days of
antibiotic therapy after source control for complicated intra-abdominal infections (cIAIs) …