Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Purpose Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder with many
complex pathways feeding into its pathogenesis and progression. Vitamin C, an essential …

The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

Severe and long-term vitamin C deficiency can lead to fatal scurvy, which is fortunately
considered rare today. However, a moderate state of vitamin C (vitC) deficiency …

Our recent work on genetic epilepsy (GE) has identified common mechanisms between GE
and neurodegenerative diseases including Alzheimer's disease (AD). Although both …

Clinical studies have reported that increased epileptiform and subclinical epileptiform
activity can be detected in many patients with an Alzheimer's disease (AD) diagnosis using …

Previously, we successfully established a d-galactose (d-gal)-induced astrocyte aging
model in vitro. However, whether the changes in the aged astrocytes induced by d-gal are …

Ascorbic acid, the reduced form of vitamin C, is a ubiquitous small carbohydrate. In spite of
decades of focused research, new metabolic functions of this universal electron donor are …

Dopamine (DA) has important roles in learning, memory, and motivational processes and is
highly susceptible to oxidation. In addition to dementia, Alzheimer's disease (AD) patients …