Chemotherapy has historically been the mainstay of cancer treatment, but our
understanding of what drives a successful therapeutic response remains limited. The …

Fibroblasts have a considerable functional and molecular heterogeneity and can play
various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL …

The study of the tumor microenvironment (TME) has become an important part of colorectal
cancer (CRC) research. Indeed, it is now accepted that the invasive character of a primary …

Simple Summary Tumor cells struggle to survive following treatment. The struggle ends in
either of two ways. The drug combination used for the treatment blocks the proliferation of …

The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, shown to
play a role in the pathogenesis of intestinal diseases such as Inflammatory Bowel Disease …

Abstract IL-1α and IL-1β are both involved in several aspects of tumor biology, including
tumor initiation, progression, metastasis, and not least in resistance to various therapies. IL …

Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …

Objective Gastric cancer (GC) is one of the malignant tumors with the highest mortality
worldwide. Our previous studies have revealed that LINC00691 is up-regulated in serum of …

Resistance to anti-cancer treatments is a critical and widespread health issue that has
brought serious impacts on lives, the economy and public policies. Mounting research has …

Abstract Background and Purpose Colorectal cancer progression from adenoma to cancer is
a time‐intensive process; however, the interaction between normal fibroblasts (NFs) with …