[HTML][HTML] Antibody–Drug Conjugates for Multiple Myeloma: Just the Beginning, or the Beginning of the End?

U Ray, RZ Orlowski - Pharmaceuticals, 2023 - mdpi.com
Multiple myeloma is a malignancy of immunoglobulin-secreting plasma cells that is now
often treated in the newly diagnosed and relapsed and/or refractory settings with …

[HTML][HTML] Targeting BCMA to treat multiple myeloma: Updates from the 2021 ASH annual meeting

R Guo, W Lu, Y Zhang, X Cao, X Jin… - Frontiers in …, 2022 - frontiersin.org
With the gradual improvement of treatment regimens, the survival time of multiple myeloma
(MM) patients has been significantly prolonged. Even so, MM is still a nightmare with an …

Real‐world experience with belantamab mafodotin therapy for relapsed/refractory multiple myeloma: a multicentre retrospective study

T Shragai, H Magen, N Lavi, M Gatt… - British Journal of …, 2023 - Wiley Online Library
Belantamab mafodotin, an immuno‐conjugate targeting B‐cell maturation antigen, showed
single‐agent activity in phase 1 and 2 studies, and was recently approved for heavily …

[HTML][HTML] Belantamab mafodotin in patients with relapsed/refractory multiple myeloma: results of the compassionate use or the expanded access program in Spain

J de la Rubia, R Alonso, ME Clavero, E Askari… - Cancers, 2023 - mdpi.com
Simple Summary Patients with multiple myeloma (MM) who become refractory to three or
more lines of therapy (RRMM patients) have few valid therapeutic alternatives. Among them …

Impact of belantamab mafodotin‐induced ocular toxicity on outcomes of patients with advanced multiple myeloma

JP Abeykoon, J Vaxman, SV Patel… - British journal of …, 2022 - Wiley Online Library
Belantamab mafodotin (BLMF) is a B‐cell maturation antigen‐directed antibody‐drug
conjugate, recently approved for advanced multiple myeloma (MM). The impact of BLMF …

[HTML][HTML] Real-world outcomes of belantamab mafodotin for relapsed/refractory multiple myeloma (RRMM): preliminary results of a Spanish expanded access program …

A Alegre, G Benzo, R Alonso, J Martínez-López… - Oncology and …, 2023 - Springer
Introduction Belantamab mafodotin (BM) is a new anti-BCMA antibody–drug conjugate,
recently approved for triple-class relapsed and refractory multiple myeloma (RRMM). We …

[HTML][HTML] Outcomes of Penta-Refractory Multiple Myeloma Patients Treated with or without BCMA-Directed Therapy

S Atrash, A Mammadzadeh, F Peng, O Alkharabsheh… - Cancers, 2023 - mdpi.com
Simple Summary Refractoriness to the five main myeloma treatments, including
lenalidomide, pomalidomide, bortezomib, carfilzomib, and either daratumumab or …

On the continuous (R) evolution of antibody-based and CAR T cell therapies in multiple myeloma: an early 2022 glance into the future

V Sunder-Plassmann, O Aksoy, J Lind… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The pace at which the identification of novel therapeutic targets has led to the
approval of multiple myeloma (MM) agents during the last two decades is nothing more than …

BCMA-targeted therapies for multiple myeloma: strategies to maximize efficacy and minimize adverse events

E Watson, F Djebbari, A Rampotas… - Expert Review of …, 2022 - Taylor & Francis
Introduction Immunotherapies targeting B cell maturation antigen (BCMA) in multiple
myeloma are transitioning through trials and entering the clinic, and will likely become a …

Real-world use of belantamab mafodotin in relapsed/refractory multiple myeloma: a systematic review

A Nanah, S Al Hadidi - JAP Academy Journal, 2023 - journal.japacademy.org
Belantamab mafodotin is an antibody drug conjugate directed against B-cell maturation
antigen and was approved by the Food and Drug Administration under accelerated approval …