The lineage transition between epithelium and mesenchyme is a process known as
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …

Aims: Induced pluripotent stem (iPS) cells have a developmental potential similar to that of
blastocyst-derived embryonic stem (ES) cells and may serve as an autologous source of …

Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2
(PRC2) regulates the balance between self-renewal and differentiation of embryonic stem …

Background While the morbidity and mortality from cancer are largely attributable to its
metastatic dissemination, the integral features of the cascade are not well understood. The …

Several reports suggest that malignant cells generate phenotypic diversity through fusion
with various types of stromal cells within the tumor microenvironment. Mesenchymal stem …

Mouse embryonic stem cells (ESCs) proliferate with rapid cell cycle kinetics but without loss
of pluripotency. The histone methyltransferase Dot1L is responsible for methylation of …

Embryonic stem cells (ESCs) can instruct the conversion of differentiated cells toward
pluripotency following cell-to-cell fusion by a mechanism that is rapid but poorly understood …

Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug
resistance and thus remains a major challenge for the treatment of melanoma and other …

Cell electrofusion in microfluidic devices attracted great attention in recent years due to its
widespread applications potential in cell-based studies. In these microfluidic devices, many …

Highlights•Cell–cell fusion is a tractable system for studying the earliest events in lineage
reprogramming.•There is untapped potential to combine cell–cell fusion and single cell …