The RNA polymerase II carboxy-terminal domain (CTD) code
D Eick, M Geyer - Chemical reviews, 2013 - ACS Publications
The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …
nucleic acid-based universal code for the maintenance and inheritance of genetic …
Transcriptional and posttranscriptional regulation of HIV-1 gene expression
J Karn, CM Stoltzfus - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting
with target RNA molecules, binding site identification by UV crosslinking and …
with target RNA molecules, binding site identification by UV crosslinking and …
Human METTL16 is a N6‐methyladenosine (m6A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
AS Warda, J Kretschmer, P Hackert, C Lenz… - EMBO …, 2017 - embopress.org
Abstract N 6‐methyladenosine (m6A) is a highly dynamic RNA modification that has recently
emerged as a key regulator of gene expression. While many m6A modifications are installed …
emerged as a key regulator of gene expression. While many m6A modifications are installed …
RNA polymerase II elongation control
Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …
CDK9: a signaling hub for transcriptional control
CW Bacon, I D'Orso - Transcription, 2019 - Taylor & Francis
ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …
transcription initiation, elongation, and termination in several key biological processes …
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP
SW Olson, AMW Turner, JW Arney, I Saleem… - Molecular cell, 2022 - cell.com
Summary 7SK is a conserved noncoding RNA that regulates transcription by sequestering
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …
The race to decipher the top secrets of TOP mRNAs
O Meyuhas, T Kahan - Biochimica et Biophysica Acta (BBA)-Gene …, 2015 - Elsevier
Cells encountering hostile growth conditions, like those residing in the middle of a newly
developing solid tumor, conserve resources and energy by downregulating protein …
developing solid tumor, conserve resources and energy by downregulating protein …
Targeting CDK9 for anti-cancer therapeutics
R Mandal, S Becker, K Strebhardt - Cancers, 2021 - mdpi.com
Simple Summary CDK9, in combination with Cyclin T1, is one of the major regulators of RNA
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …
[HTML][HTML] HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
B Sobhian, N Laguette, A Yatim, M Nakamura, Y Levy… - Molecular cell, 2010 - cell.com
HIV-1 transactivator Tat has greatly contributed to our understanding of transcription
elongation by RNAPII. We purified HIV-1 Tat-associated factors from HeLa nuclear extract …
elongation by RNAPII. We purified HIV-1 Tat-associated factors from HeLa nuclear extract …