ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in
Chinese people in December 2019 and has currently spread worldwide causing the COVID …
Chinese people in December 2019 and has currently spread worldwide causing the COVID …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure
LB Arendse, AHJ Danser, M Poglitsch, RM Touyz… - Pharmacological …, 2019 - Elsevier
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance
K Sriram, PA Insel - British journal of pharmacology, 2020 - Wiley Online Library
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
An update on the tissue renin angiotensin system and its role in physiology and pathology
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine
system involved in blood pressure regulation and body electrolyte balance. However, the …
system involved in blood pressure regulation and body electrolyte balance. However, the …
SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy
Background SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-
converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or …
converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or …
Angiotensin II-induced signal transduction mechanisms for cardiac hypertrophy
SK Bhullar, NS Dhalla - Cells, 2022 - mdpi.com
Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …
Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function
RC Edenfield, CA Easley IV - Nature Reviews Urology, 2022 - nature.com
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively
little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection …
little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection …
Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID
SL Cooper, E Boyle, SR Jefferson, CRA Heslop… - International Journal of …, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
Y Namkung, C LeGouill, S Kumar, Y Cao… - Science …, 2018 - science.org
G protein–coupled receptors (GPCRs) are important therapeutic targets that exhibit
functional selectivity (biased signaling), in which different ligands or receptor variants elicit …
functional selectivity (biased signaling), in which different ligands or receptor variants elicit …