In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Wave-like propagation of [Ca2+] i increases is a remarkable intercellular communication
characteristic in astrocyte networks, intercalating neural circuits and vasculature …

Ca2+ entry through transmitter-gated cation channels, including ATP-gated P2X channels,
contributes to an array of physiological processes in excitable and non-excitable cells, but …

Extracellular adenosine 5′-triphosphate (ATP) has been recognized as a ubiquitous,
unstable signalling molecule, acting as a fast neurotransmitter and modulator of transmitter …

Following hints in the early literature about adenosine 5′-triphosphate (ATP) injections
producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype …

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly
gaining recognition and this is a comprehensive review of early and recent publications in …

Background The use of chloral hydrate as a sole maintenance anesthetic agent in rodent
research has been controversial due to statements made in reference literature conflicting …

Background/Aims: ATP-gated P2X 4 purinergic receptors (P2X 4 Rs) are cation channels
with important roles in diverse cell types. To date, lack of specific inhibitors has hampered …

Purine and pyrimidine nucleotides have been identified as potent extracellular signalling
molecules, acting at two classes of cell surface receptors, ionotropic P2X and metabotropic …