Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-
stage embryos, have emerged as a powerful tool to study the early stages of mammalian …

The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …

Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …

Gastruloids are three-dimensional aggregates of embryonic stem cells that display key
features of mammalian development after implantation, including germ-layer specification …

The emergence of multiple axes is an essential element in the establishment of the
mammalian body plan. This process takes place shortly after implantation of the embryo …

Cell fate transitions are frequently accompanied by changes in cell shape and mechanics.
However, how cellular mechanics affects the instructive signaling pathways controlling cell …

The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …

The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …