The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …

Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …

Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …

Primary cilia are non‐motile antennae‐like structures responsible for sensing environmental
changes in most mammalian cells. Ciliary signalling is largely mediated by the Sonic …

Neurulation, the early embryonic process of forming the presumptive brain and spinal cord,
is highly complex and involves hundreds of genes in multiple genetic pathways. Mice have …

Structural birth defects are a leading cause of mortality and morbidity in children world‐wide,
affecting as much as 6% of all live births. Among these conditions, neural tube defects …

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [194], for which
preliminary evidence for an endogenous ligand has been published, or for which there …

During embryonic development, the central nervous system forms as the neural plate and
then rolls into a tube in a complex morphogenetic process known as neurulation. Neural …