Breast cancer heterogeneity and its implication in personalized precision therapy

L Guo, D Kong, J Liu, L Zhan, L Luo, W Zheng… - … hematology & oncology, 2023 - Springer
Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …

Omics-based deep learning approaches for lung cancer decision-making and therapeutics development

TO Tran, TH Vo, NQK Le - Briefings in Functional Genomics, 2024 - academic.oup.com
Lung cancer has been the most common and the leading cause of cancer deaths globally.
Besides clinicopathological observations and traditional molecular tests, the advent of …

Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling

P Pati, S Karkampouna, F Bonollo… - Nature Machine …, 2024 - nature.com
Understanding the spatial heterogeneity of tumours and its links to disease initiation and
progression is a cornerstone of cancer biology. Presently, histopathology workflows heavily …

Tumor heterogeneity: preclinical models, emerging technologies, and future applications

M Proietto, M Crippa, C Damiani, V Pasquale… - Frontiers in …, 2023 - frontiersin.org
Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

Aberrant LYZ expression in tumor cells serves as the potential biomarker and target for HCC and promotes tumor progression via csGRP78

Z Gu, L Wang, Q Dong, K Xu, J Ye… - Proceedings of the …, 2023 - National Acad Sciences
Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

Towards artificial intelligence to multi-omics characterization of tumor heterogeneity in esophageal cancer

J Li, L Li, P You, Y Wei, B Xu - Seminars in Cancer Biology, 2023 - Elsevier
Esophageal cancer is a unique and complex heterogeneous malignancy, with substantial
tumor heterogeneity: at the cellular levels, tumors are composed of tumor and stromal …

Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer

MK Bakht, H Beltran - Nature Reviews Urology, 2024 - nature.com
Prostate-specific membrane antigen (PSMA) is an important cell-surface imaging biomarker
and therapeutic target in prostate cancer. The PSMA-targeted theranostic 177Lu-PSMA-617 …

Explainable artificial intelligence for drug discovery and development-a comprehensive survey

R Alizadehsani, SS Oyelere, S Hussain… - IEEE …, 2024 - ieeexplore.ieee.org
The field of drug discovery has experienced a remarkable transformation with the advent of
artificial intelligence (AI) and machine learning (ML) technologies. However, as these AI and …

Towards interpretable imaging genomics analysis: methodological developments and applications

X Cen, W Dong, W Lv, Y Zhao, F Dubee, AFA Mentis… - Information …, 2024 - Elsevier
Identifying the relationship between imaging features and genetic variation (a term coined
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …

Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to …

T Vo, B Balderson, K Jones, G Ni, J Crawford, A Millar… - Genome Medicine, 2023 - Springer
Background Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be
classified into four major subgroups based on gene expression and genomic features …