Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …

The pineal product melatonin has remarkable antioxidant properties. It is secreted during
darkness and plays a key role in various physiological responses including regulation of …

Melatonin was recently reported to be an effective free radical scavenger and antioxidant.
Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Melatonin, or N‐acetyl‐5‐methoxytryptamine, is a compound derived from tryptophan that is
found in all organisms from unicells to vertebrates. This indoleamine may act as a protective …

The worldwide prolongation of the mean life expectancy has resulted in a rapid increase of
the size of the elderly population (over the age of 60), both in numbers and as a proportion …

Melatonin is a natural occurring compound with well-known antioxidant properties. In the
last decade a new effect of melatonin on mitochondrial homeostasis has been discovered …

Antioxidant enzymes (AOEs) are part of the primary cellular defense against free radicals
induced by toxins and/or spontaneously formed in cells. Melatonin (MLT) has received much …