Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

Gut microorganisms modulate host phenotypes and are associated with numerous health
effects in humans, ranging from host responses to cancer immunotherapy to metabolic …

Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …

Depression is a global health concern affecting nearly 280 million individuals. It not only
imposes a significant burden on economies and healthcare systems but also manifests …

Neurodegenerative disorders are diseases characterized by progressive degeneration of
neurons and associated structures and are a major global issue growing more widespread …

Chronic maternal ethanol exposure leads to poor intelligence, impaired cognition and array
of neurological symptoms in offsprings and commonly referred as fetal alcohol spectrum …

Epidemiological studies indicated that mood disorders like depression and anxiety are
highly prevalent in type-II diabetes mellitus (T2DM). However, the neurobiological …

Neuroinflammation and microglial activation, common components of most
neurodegenerative diseases, can be imitated in vitro by challenging microglia cells with Lps …

Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown
significant potential for neuroprotection in Parkinson's Disease (PD) due to its multifaceted …