Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Whey-based diets have been linked with prolonged life expectancy and improved physical
performance. These observations based on numerous clinical and simulated studies are …

The formation of noncovalent complexes by mixing of positively charged polymers with
negatively charged oligonucleotides (ONs) is a widely explored concept in nanomedicine to …

Uterine leiomyoma (UL) is a prevalent benign tumor in women that frequently gives rise to a
multitude of reproductive complications. The use of suicide gene therapy has been …

Suicide gene therapy was suggested as a possible strategy for the treatment of uterine
fibroids (UFs), which are the most common benign tumors inwomen of reproductive age. For …

Uterine leiomyoma is the most common benign tumor of the reproductive system. Current
therapeutic options do not simultaneously meet the requirements of long-term efficiency and …

Anti-angiogenic RNAi-based therapy can be considered as a possible strategy for the
treatment of endometriosis (EM), which is the most common gynecological disease …

The application of small interfering RNA (siRNA) for specific gene inhibition is a promising
strategy in gene therapy treatments. The efficient cellular delivery of therapeutic siRNA is a …

Abstract Development of gene therapy for endometriosis requires inhibition of
vascularization in endometrial lesions. We have previously developed CXCR4 receptor …

The major barriers for intracellular DNA transportation by cationic polymers are their toxicity,
poor endosomal escape and inefficient nuclear uptake. Therefore, we designed novel …