The infectious etiology of Alzheimer's disease

M Sochocka, K Zwolinska… - Current …, 2017 - ingentaconnect.com
Background: Inflammation is a part of the first line of defense of the body against invasive
pathogens, and plays a crucial role in tissue regeneration and repair. A proper inflammatory …

Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity

M Pohanka - International journal of molecular sciences, 2014 - mdpi.com
Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of
Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of …

The possibility of an infectious etiology of Alzheimer disease

GM Ashraf, VV Tarasov, A Makhmutovа… - Molecular …, 2019 - Springer
Over the past three decades, there has been constant postulation regarding the infectious
etiology of Alzheimer disease (AD), which in turn suggests the vital role of various infectious …

Experimental drugs in randomized controlled trials for long-COVID: what's in the pipeline? A systematic and critical review

SJ Yong, A Halim, M Halim, LC Ming… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Over three years have passed since the emergence of coronavirus disease
2019 (COVID-19), and yet the treatment for long-COVID, a post-COVID-19 syndrome …

Microglia signaling as a target of donepezil

J Hwang, H Hwang, HW Lee, K Suk - Neuropharmacology, 2010 - Elsevier
Donepezil is a reversible and noncompetitive cholinesterase inhibitor. The drug is
considered as a first-line treatment in patients with mild to moderate Alzheimer's disease …

Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens

DM Czyż, LP Potluri, N Jain-Gupta, SP Riley… - MBio, 2014 - Am Soc Microbiol
We sought a new approach to treating infections by intracellular bacteria, namely, by altering
host cell functions that support their growth. We screened a library of 640 Food and Drug …

Donepezil regulates 1-methyl-4-phenylpyridinium-induced microglial polarization in Parkinson's disease

T Chen, R Hou, S Xu, C Wu - ACS Chemical Neuroscience, 2015 - ACS Publications
1-Methyl-4-phenylpyridinium (MPP+) induces microglial activation and degeneration of
dopaminergic (DAergic) neurons. Donepezil is a well-known acetylcholinesterase inhibitor …

[HTML][HTML] Donepezil beyond Alzheimer's disease? A narrative review of therapeutic potentials of donepezil in different diseases

P Pooladgar, M Sakhabakhsh, A Taghva… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Donepezil hydrochloride is an acetylcholine esterase inhibitor studied and approved to treat
Alzheimer's disease (AD). However, this drug can have positive therapeutic potential in …

The innate immunity in Alzheimer disease-relevance to pathogenesis and therapy

Z Blach-Olszewska, E Zaczynska… - Current …, 2015 - benthamdirect.com
The genetic, cellular, and molecular changes associated with Alzheimer disease provide
evidence of immune and inflammatory processes involvement in its pathogenesis. These …

The influence of donepezil and EGb 761 on the innate immunity of human leukocytes: effect on the NF-κB system

M Sochocka, E Zaczyńska, A Taboł, A Czarny… - International …, 2010 - Elsevier
Ginkgo biloba special extract EGb 761 and donepezil are drugs used in Alzheimer therapy.
The influence of donepezil and EGb 761 on two mechanisms of innate immunity, natural …