Aggressive B‐cell lymphomas in the update of the 4th edition of the World Health Organization classification of haematopoietic and lymphatic tissues: refinements of …

G Ott - British journal of haematology, 2017 - Wiley Online Library
The update of the 4th edition of the World Health Organization Classification of
Haematopoietic and Lymphatic Tissues portends important new findings and concepts in the …

Integrating precision medicine through evaluation of cell of origin in treatment planning for diffuse large B-cell lymphoma

GS Nowakowski, T Feldman, LM Rimsza… - Blood cancer …, 2019 - nature.com
Precision medicine is modernizing strategies for clinical study design to help improve
diagnoses guiding individualized treatment based on genetic or phenotypic characteristics …

Cell‐of‐origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B‐cell …

M Abdulla, P Hollander, T Pandzic… - American journal of …, 2020 - Wiley Online Library
The tumor cells in diffuse large B‐cell lymphomas (DLBCL) are considered to originate from
germinal center derived B‐cells (GCB) or activated B‐cells (ABC). Gene expression profiling …

A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL

ZY Xu-Monette, H Zhang, F Zhu, A Tzankov… - Blood …, 2020 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of B-cell lymphoma. Cell-
of-origin (COO) classification of DLBCL is required in routine practice by the World Health …

MYC/BCL2 co-expression is a stronger prognostic factor compared with the cell-of-origin classification in primary CNS DLBCL

QY Shi, X Feng, W Bao, J Ma, JH Lv… - … of Neuropathology & …, 2017 - academic.oup.com
Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a subtype
of DLBCL with an unfavorable prognosis and a poor response to the treatment. As we know …

Recent advances in aggressive large B-cell lymphomas: a comprehensive review

P Korkolopoulou, T Vassilakopoulos… - Advances in …, 2016 - journals.lww.com
Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with considerable
heterogeneity reflected in the 2008 World Health Organization classification. In recent years …

Targetable subsets of non-Hodgkin lymphoma in Malawi define therapeutic opportunities

EA Morgan, MP Sweeney, T Tomoka, N Kopp… - Blood …, 2016 - ashpublications.org
Diagnostics and supportive care for patients with non-Hodgkin lymphoma (NHL) in lower-
and middle-income countries (LMICs) are lacking. We hypothesized that high-throughput …

MYC/BCL2 double-expression vs. cell-of-origin classification in diffuse large B-cell lymphoma: do we need to know both?

AR Sohani, JS Abramson - Leukemia & Lymphoma, 2016 - Taylor & Francis
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma
and demonstrates significant clinicopathologic and genetic heterogeneity. In 2000, Alizadeh …

Molecular Applications in Hematolymphoid Cytology

J Schwock, GR Quest, WR Geddie - Molecular Applications in Cytology, 2018 - Springer
Fine needle samples of lymph nodes and extranodal lymphoid tissues are common in
cytopathology practice. Diagnosis and classification of hematolymphoid disorders has been …

[HTML][HTML] Clinical applications of genome studies

A Younes - Hematological oncology, 2017 - ncbi.nlm.nih.gov
In 2017, it is estimated that 80 000 new patients will be diagnosed with non-Hodgkin
lymphoma (NHL) in the United States. 1 The NHLs are classified into more than 60 …