Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems
Allostasis, originally conceptualized to explain persistent morbidity of arousal and autonomic
function, is defined as the process of achieving stability through physiological or behavioral …
function, is defined as the process of achieving stability through physiological or behavioral …
Negative affective states and cognitive impairments in nicotine dependence
Smokers have substantial individual differences in quit success in response to current
treatments for nicotine dependence. This observation may suggest that different underlying …
treatments for nicotine dependence. This observation may suggest that different underlying …
Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety
Nicotine stimulates dopamine (DA) neurons of the ventral tegmental area (VTA) to establish
and maintain reinforcement. Nicotine also induces anxiety through an as yet unknown …
and maintain reinforcement. Nicotine also induces anxiety through an as yet unknown …
VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation
Dopaminergic neurons in the ventral tegmental area (VTA) are well known for mediating the
positive reinforcing effects of drugs of abuse. Here we identify in rodents and humans a …
positive reinforcing effects of drugs of abuse. Here we identify in rodents and humans a …
BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions
H Vargas-Perez, A Bahi, MR Bufalino… - Journal of …, 2014 - Soc Neuroscience
Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized
to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural …
to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural …
Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking
Much evidence indicates that individuals use tobacco primarily to experience the
psychopharmacological properties of nicotine and that a large proportion of smokers …
psychopharmacological properties of nicotine and that a large proportion of smokers …
β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward
TE Grieder, M Besson, G Maal-Bared… - Proceedings of the …, 2019 - National Acad Sciences
Evidence shows that the neurotransmitter dopamine mediates the rewarding effects of
nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate the …
nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate the …
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational
symptoms during withdrawal that contribute to relapse in dependent individuals. The …
symptoms during withdrawal that contribute to relapse in dependent individuals. The …
[HTML][HTML] Negative dimension in psychiatry. Amotivational syndrome as a paradigm of negative symptoms in substance abuse
L Rovai, AGI Maremmani, M Pacini, PP Pani… - Rivista di …, 2013 - rivistadipsichiatria.it
Negative symptoms, conceptualized as clinical manifestations of schizophrenia, and
subsequently described in other psychiatric disorders, include the loss of normal arousal …
subsequently described in other psychiatric disorders, include the loss of normal arousal …
A DRD2 and ANKK1 haplotype is associated with nicotine dependence
J Voisey, CD Swagell, IP Hughes, A van Daal… - Psychiatry …, 2012 - Elsevier
To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence,
150 smokers and 228 controls were genotyped for the DRD2 C957T,-141delC and ANKK1 …
150 smokers and 228 controls were genotyped for the DRD2 C957T,-141delC and ANKK1 …