Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1, 3 kinase/protein kinase B (PI3K/AKT) …

PG Artini, C Tatone, S Sperduti, M D'Aurora… - Human …, 2017 - academic.oup.com
STUDY QUESTION Is the phosphoinositol 1, 3-kinase/protein kinase B (PI3K/AKT) pathway
expression profile in cumulus cells (CCs) a potential marker of oocyte competence and …

N-acetyl-L-cysteine improves the developmental competence of bovine oocytes and embryos cultured in vitro by attenuating oxidative damage and apoptosis

WS Sun, H Jang, MR Park, KB Oh, H Lee, S Hwang… - Antioxidants, 2021 - mdpi.com
Oxidative stress has been suggested to negatively affect oocyte and embryo quality and
developmental competence, resulting in failure to reach full term. In this study, we …

BPA and BPS affect Connexin 37 in bovine cumulus cells

R Sabry, C Apps, JA Reiter-Saunders, AC Saleh… - Genes, 2021 - mdpi.com
Bisphenol S (BPS) is used as an alternative plasticizer to Bisphenol A (BPA), despite limited
knowledge of potential adverse effects. BPA exhibits endocrine disrupting effects during …

Competence classification of cumulus and granulosa cell transcriptome in embryos matched by morphology and female age

R Borup, LL Thuesen, CY Andersen… - PloS one, 2016 - journals.plos.org
Objective By focussing on differences in the mural granulosa cell (MGC) and cumulus cell
(CC) transcriptomes from follicles resulting in competent (live birth) and non-competent (no …

Aspectos esenciales sobre las técnicas de fertilización in vitro en bovinos

E Salgado-Cruz, R Lopera-Vásquez - Revista de Investigaciones …, 2020 - scielo.org.pe
La producción de embriones in vitro incluye un conjunto de técnicas utilizadas para la
multiplicación en condiciones de laboratorio de líneas de animales genéticamente …

Use of both cumulus cells' transcriptomic markers and zona pellucida birefringence to select developmentally competent oocytes in human assisted reproductive …

M Assidi, M Montag, MA Sirard - BMC genomics, 2015 - Springer
Background Selection of the best oocyte for subsequent steps of fertilization and embryo
transfer was shown to be the crucial step in human infertility treatment procedure. Oocyte …

Association between cumulus cells—mRNA levels of AMHR2 and FSHR with oocyte maturity

F Montazeri, SM Kalantar, F Fesahat… - Middle East Fertility …, 2022 - Springer
Background The gene expression of anti-Mullerian hormone receptor type 2 (AMHR2) and
follicle stimulating hormone receptor (FSHR) in cumulus cells (CCs) isolated from mature …

Cumulus cell DNA damage linked to fertilization success in females with an ovulatory dysfunction phenotype

B Rodrigues, V Sousa, F Esteves… - Frontiers in Cell and …, 2024 - frontiersin.org
Intracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI
success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which …

Mitochondrial Dysfunction in Advanced Maternal Aged Cumulus Cells: A Possible Link to ATP Synthase Impairment?

S Almeida-Reis, A Carvalho, C Dias, R Brito, R Silva… - Biomolecules, 2024 - mdpi.com
Age-related changes in the mitochondrial status of human cumulus cells (hCCs) impact
oocyte quality; however, the relationship between hCC mitochondrial (dys) function and …

Retinoic Acid Action in Cumulus Cells: Implications for Oocyte Development and In Vitro Fertilization

N Sidell, A Rajakumar - International Journal of Molecular Sciences, 2024 - mdpi.com
In the field of human in vitro fertilization (IVF), selecting the best oocyte for freezing or
embryo for transfer remains an important focus of clinical practice. Although several …