Currently, cancer metastases remain a major clinical problem that highlights the importance
of recognition of the metastatic process in cancer diagnosis and treatment. A critical process …

Invasion and metastasis are malignant phenotypes in cancer that lead to patient death. Cell
motility is involved in these processes. In 1998, we identified overexpression of the actin …

Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and
despite treatment advances, patient prognosis remains poor. During routine animal studies …

Medulloblastoma (MB) and gliomas are the most frequent high-grade brain tumors (HGBT)
in children and adulthood, respectively. The general treatment for these tumors consists in …

Alpha-actinins (ACTNs) were originally identified as cytoskeletal proteins which cross-link
filamentous actin to establish cytoskeletal architect that protects cells from mechanical stress …

Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to
date have not been translated into effective therapy, necessitating pursuit of alternative …

Microtubules are dynamic tubular polymers of α-and β-tubulin which provide structural
integrity, promote migration, transport of molecules, vesicles and organelles and play …

The initiation of T-cell signaling is critically dependent on the function of the member of Src
family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase …

Actinin-4 is an isoform of nonmuscular α-actinin and actin-bundling protein that plays an
important role in cancer invasion and metastasis by enhancing cellular motility. Recent …

Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor
survival rates. The current standard treatment includes chemotherapy with temozolomide …