Beyond the cell factory: Homeostatic regulation of and by the UPRER

MG Metcalf, R Higuchi-Sanabria, G Garcia, CK Tsui… - Science …, 2020 - science.org
The endoplasmic reticulum (ER) is commonly referred to as the factory of the cell, as it is
responsible for a large amount of protein and lipid synthesis. As a membrane-bound …

Endoplasmic reticulum stress signaling in cancer and neurodegenerative disorders: Tools and strategies to understand its complexity

DC da Silva, P Valentão, PB Andrade… - Pharmacological …, 2020 - Elsevier
The endoplasmic reticulum (ER) comprises a network of tubules and vesicles that
constitutes the largest organelle of the eukaryotic cell. Being the location where most …

In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains

TR Hawkinson, HA Clarke, LEA Young… - Alzheimer's & …, 2022 - Wiley Online Library
N‐linked protein glycosylation in the brain is an understudied facet of glucose utilization that
impacts a myriad of cellular processes including resting membrane potential, axon firing …

Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity

DW Heindel, S Koppolu, Y Zhang… - Proceedings of the …, 2020 - National Acad Sciences
Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5
million cases of severe illness and∼ 290,000 to 645,000 deaths annually worldwide. The …

Site-specific characterization of SARS-CoV-2 spike glycoprotein receptor-binding domain

A Antonopoulos, S Broome, V Sharov… - …, 2021 - academic.oup.com
The novel coronavirus SARS-CoV-2, the infective agent causing COVID-19, is having a
global impact both in terms of human disease as well as socially and economically. Its …

Viral evolution shaped by host proteostasis networks

J Yoon, JE Patrick, CB Ogbunugafor… - Annual Review of …, 2023 - annualreviews.org
Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …

Integrated omics and computational glycobiology reveal structural basis for influenza A virus glycan microheterogeneity and host interactions

K Khatri, JA Klein, MR White, OC Grant… - Molecular & Cellular …, 2016 - ASBMB
Despite sustained biomedical research effort, influenza A virus remains an imminent threat
to the world population and a major healthcare burden. The challenge in developing …

Towards understanding the extensive diversity of protein N‐glycan structures in eukaryotes

C Toustou, ML Walet‐Balieu… - Biological …, 2022 - Wiley Online Library
ABSTRACT N‐glycosylation is an important post‐translational modification of proteins that
has been highly conserved during evolution and is found in Eukaryota, Bacteria and …

Multi-level regulation of cellular glycosylation: from genes to transcript to enzyme to structure

S Neelamegham, LK Mahal - Current opinion in structural biology, 2016 - Elsevier
Highlights•Glycosylation is regulated at the transcriptional, translational and post-
translational levels.•Advances in sequencing and structural analysis enable data collection …

Modulation of endoplasmic reticulum stress response pathways by respiratory viruses

KL Macauslane, CL Pegg, KR Short… - Critical reviews in …, 2024 - Taylor & Francis
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability,
and the greatest burden of disease impacts children, pregnant women, and the elderly …