Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate
the transcriptional functions of nuclear receptors and other transcription factors, and are the …

Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro
bonds in certain proteins, thereby inducing conformational changes. Such conformational …

Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …

Transcriptional coregulators (coactivators and corepressors) have emerged as the principal
modulators of the functions of nuclear receptors and other transcription factors. During the …

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and
so affect protein function and/or stability. PIN1 regulates a number of proteins important for …

Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the
expression of specific subsets of genes in a ligand-dependent manner. The basic …

Nuclear receptor (NR) coregulators (coactivators and corepressors) are essential elements
in regulating nuclear receptor-mediated transcription. In a little more than a decade since …

Summary Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncogene frequently amplified
and overexpressed in breast cancers. Here we report that SRC-3 interacts with REGγ, a …

Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …