Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Traumatic peripheral nerve injury represents a major clinical and public health problem that
often leads to significant functional impairment and permanent disability. Despite modern …

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a
broad array of cellular changes. Here we show that the let-7 family of microRNAs acts as an …

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription
factors that are activated by axonal signals and control the generation of myelin-forming …

Cutaneous wound healing is a complex process that aims to re-establish the original
structure of the skin and its functions. Among other disorders, peripheral neuropathies are …

Glial cells and neurons are engaged in a continuous and highly regulated bidirectional
dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central …

During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons
will transit through a promyelinating stage before exiting the cell cycle and initiating myelin …