Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2
MM Muley, AR Reid, B Botz, K Boelcskei… - British journal of …, 2016 - Wiley Online Library
Background and Purpose Neutrophil elastase plays a crucial role in arthritis. Here, its
potential in triggering joint inflammation and pain was assessed, and whether these effects …
potential in triggering joint inflammation and pain was assessed, and whether these effects …
Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models
The extracellular signal-regulated kinase (ERK) isoforms, ERK1 and ERK2, are believed to
be key signaling molecules in nociception and nociceptive sensitization. Studies using …
be key signaling molecules in nociception and nociceptive sensitization. Studies using …
Spinophilin-targeted protein phosphatase-1 alleviated inflammatory pain by negative control of MEK/ERK signaling in spinal cord dorsal horn of rats
XD Hu, YN Liu, ZY Zhang, ZA Ma, ZW Suo… - Journal of …, 2015 - Soc Neuroscience
Protein phosphatase-1 (PP1), anchored by regulatory or targeting proteins at excitatory
glutamatergic synapses, controls the phosphorylation of postsynaptic substrates and …
glutamatergic synapses, controls the phosphorylation of postsynaptic substrates and …
ERK2 alone drives inflammatory pain but cooperates with ERK1 in sensory neuron survival
DE O'Brien, BJ Alter, M Satomoto… - Journal of …, 2015 - Soc Neuroscience
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are highly homologous yet distinct
components of signal transduction pathways known to regulate cell survival and function …
components of signal transduction pathways known to regulate cell survival and function …
Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain …
Q Xu, SM Garraway, AR Weyerbacher… - Journal of …, 2008 - Soc Neuroscience
Extracellular signal-regulated kinase 1 (ERK1) and ERK2 signaling in the spinal cord dorsal
horn (SCDH) has been implicated in injury-induced pain hypersensitivity. Available ERK …
horn (SCDH) has been implicated in injury-induced pain hypersensitivity. Available ERK …
Norisoboldine attenuates inflammatory pain via the adenosine A 1 receptor
X Gao, Q Lu, G Chou, Z Wang, R Pan… - … journal of pain, 2014 - Wiley Online Library
Background Norisoboldine (NOR) is a benzylisoquinoline alkaloid isolated from R adix
Linderae, a traditional C hinese medicine. Our previous studies have demonstrated that it …
Linderae, a traditional C hinese medicine. Our previous studies have demonstrated that it …
Pyruvate dehydrogenase kinase 2 and 4 gene deficiency attenuates nociceptive behaviors in a mouse model of acute inflammatory pain
Pyruvate dehydrogenase (PDH) kinases (PDKs) 1–4, expressed in peripheral and central
tissues, regulate the activity of the PDH complex (PDC). The PDC is an important …
tissues, regulate the activity of the PDH complex (PDC). The PDC is an important …
A role for extracellular signal-regulated kinases 1 and 2 in the maintenance of persistent mechanical hyperalgesia in ovariectomized mice
MB Klinger, S Sacks, F Cervero - Neuroscience, 2011 - Elsevier
Mitogen-activated protein kinases (MAPKs) are important signaling factors in many cellular
processes including cell proliferation and survival during development and synaptic …
processes including cell proliferation and survival during development and synaptic …
Pain treatment using ERK2 inhibitors
CE Inturrisi, Q Xu, SM Garraway - US Patent 9,506,068, 2016 - Google Patents
US9506068B2 - Pain treatment using ERK2 inhibitors - Google Patents US9506068B2 - Pain
treatment using ERK2 inhibitors - Google Patents Pain treatment using ERK2 inhibitors …
treatment using ERK2 inhibitors - Google Patents Pain treatment using ERK2 inhibitors …
Pain treatment using ERK2 inhibitors
CE Inturrisi, Q Xu, SM Garraway - US Patent 8,951,979, 2015 - Google Patents
US8951979B2 - Pain treatment using ERK2 inhibitors - Google Patents US8951979B2 - Pain
treatment using ERK2 inhibitors - Google Patents Pain treatment using ERK2 inhibitors Download …
treatment using ERK2 inhibitors - Google Patents Pain treatment using ERK2 inhibitors Download …