[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy

J Pan, L Zhou, C Zhang, Q Xu, Y Sun - Signal transduction and targeted …, 2022 - nature.com
Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

[HTML][HTML] New insights into the roles and mechanisms of spermidine in aging and age-related diseases

YQ Ni, YS Liu - Aging and disease, 2021 - ncbi.nlm.nih.gov
High incidences of morbidity and mortality associated with age-related diseases among the
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …

[HTML][HTML] True or False? Alzheimer's disease is Type 3 Diabetes: Evidences from Bench to Bedside.

Y Peng, S Yao, Q Chen, H Jin, M Du, Y Xue… - Ageing research reviews, 2024 - Elsevier
Globally, Alzheimer's disease (AD) is the most widespread chronic neurodegenerative
disorder, leading to cognitive impairment, such as aphasia and agnosia, as well as mental …

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

R Limbocker, S Errico, D Barbut, TPJ Knowles… - Natural Product …, 2022 - pubs.rsc.org
Covering: 1993 to 2021 (mainly 2017–2021) Alzheimer's and Parkinson's diseases are
neurodegenerative conditions affecting over 50 million people worldwide. Since these …

[HTML][HTML] Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders

J Olloquequi, A Cano, E Sanchez-López… - Biomedicine & …, 2022 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …

Therapeutic application of lantibiotics and other lanthipeptides: old and new findings

ADP van Staden, WF van Zyl, M Trindade… - Applied and …, 2021 - Am Soc Microbiol
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides, with
modifications that are incorporated during biosynthesis by dedicated enzymes. Various …

Interorganelle communication, aging, and neurodegeneration

M Petkovic, CE O'Brien, YN Jan - Genes & Development, 2021 - genesdev.cshlp.org
Our cells are comprised of billions of proteins, lipids, and other small molecules packed into
their respective subcellular organelles, with the daunting task of maintaining cellular …

Dexmedetomidine provides protection against hippocampal neuron apoptosis and cognitive impairment in mice with Alzheimer's disease by mediating the miR-129 …

W Sun, J Zhao, C Li - Molecular neurobiology, 2020 - Springer
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that leads to
progressive cognitive, memory, and learning dysfunction that affects the aging population …

[HTML][HTML] SARS-CoV-2 and the central nervous system: emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations

J Mitra, M Kodavati, VE Provasek, KS Rao… - Ageing Research …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) continues to impact our lives by causing …