Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

As a substantial part of the brain tumor microenvironment (TME), glioma-associated
microglia/macrophages (GAMs) have an emerging role in tumor progression and in …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …

Neuroinflammation is a common feature in neurodegenerative diseases and strategies to
modulate neuroinflammatory processes are increasingly considered as therapeutic options …

The innate immune system is strongly implicated in the pathogenesis of Alzheimer's disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …

In atherosclerosis and Alzheimer's disease, deposition of the altered self components
oxidized low-density lipoprotein (LDL) and amyloid-β triggers a protracted sterile …

Inflammation and autophagy are two critical cellular processes. The relationship between
these two processes is complex and includes the suppression of inflammation by …

The fibrillar peptide amyloid-β (Aβ) has a chief function in the pathogenesis of Alzheimer's
disease. Interleukin 1β (IL-1β) is a key cytokine in the inflammatory response to Aβ …

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of
proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and …