Aptamer applications in emerging viral diseases

A Krüger, AP de Jesus Santos, V de Sá, H Ulrich… - Pharmaceuticals, 2021 - mdpi.com
Aptamers are single-stranded DNA or RNA molecules which are submitted to a process
denominated SELEX. SELEX uses reiterative screening of a random oligonucleotide library …

Exploring the potential of aptamers in targeting neuroinflammation and neurodegenerative disorders: Opportunities and challenges

AHY Kong, AJ Wu, OKY Ho, MMK Leung… - International Journal of …, 2023 - mdpi.com
Neuroinflammation is the precursor for several neurodegenerative diseases (NDDs), such
as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) …

Acidified sucralfate encapsulated chitosan derivative nanoparticles as oral vaccine adjuvant delivery enhancing mucosal and systemic immunity

Z Zhao, S Qiao, Z Jin, H Li, H Yu, C Zhang… - International Journal of …, 2024 - Elsevier
Oral vaccines are generally perceived to be safe, easy to administer, and have the potential
to induce both systemic and mucosal immune responses. However, given the challenges …

[HTML][HTML] Current status of oligonucleotide-based protein degraders

PC Shih, M Naganuma, Y Demizu, M Naito - Pharmaceutics, 2023 - mdpi.com
Transcription factors (TFs) and RNA-binding proteins (RBPs) have long been considered
undruggable, mainly because they lack ligand-binding sites and are equipped with flat and …

Aptamer-based tumor-targeted diagnosis and drug delivery

HB Woldekidan, AA Woldesemayat, G Adam… - Cell Biology and …, 2022 - Springer
Early cancer identification is crucial for providing patients with safe and timely therapy.
Highly dependable and adaptive technologies will be required to detect the presence of …

Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice

XY Cao, R Aimaier, J Yang, J Yang, ZY Chen, JJ Zhao… - BMC genomics, 2023 - Springer
Background Previous studies have shown that secondary metabolites of Bacillus subtilis
strain Z15 (BS-Z15) are effective in treating fungal infections in mice. To evaluate whether it …

[PDF][PDF] Application and Immunogenicity of Aptamers in Cancer Therapy

A Ghazizadeh, R Amazadeh, M Ziyamolki, A Olfati… - Biomed Res, 2023 - biomedrb.com
Aptamers are short single-stranded nucleic acid (DNA or RNA) or peptide sequences with a
unique three-dimensional structure that bind to their targets with high specificity and affinity …

Oral immunization with acidified sucralfate@ N-2-HACC/CMCS NPs elicits protective immune response in guinea pigs

Z Zhao, S Qiao, Z Jin, C Zhang, TH Yin, K Zhao - 2024 - researchsquare.com
Oral administration of vaccine is required to preserve the vaccine against degradation,
enhance antigen absorption in the gastrointestinal tract, and trigger adaptive immune …

[HTML][HTML] A Chronic Voice

F are Powerful - achronicvoice.com
Do you have a friend or know someone living with Antiphospholipid Syndrome (APS), or
another blood clotting disorder? It can be a real pain, and interferes with treatments for many …