The principal mechanism of reducing sulfur into organic compounds is via the synthesis of l-
cysteine. Cysteine is used for protein and glutathione synthesis, as well as being the primary …

The genus Neisseria includes both commensal and pathogenic species which are
genetically closely related. However, only meningococcus and gonococcus are important …

The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes
the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against …

Background Meningococcal outer membrane vesicle (OMV) vaccines are prepared with
detergents to remove endotoxin, which also remove desirable antigens such as factor H …

The problem of antibiotic resistance has prompted the search for new antibiotics with novel
mechanisms of action. Analogues of the A54556 cyclic acyldepsipeptides (ADEPs) …

Background Neisseria meningitidis expresses type four pili (Tfp) which are important for
colonisation and virulence. Tfp have been considered as one of the most variable structures …

Autotransporters (AT s) are proteins secreted by G ram‐negative bacteria that often play a
role in virulence. Eight different AT s have been identified in N eisseria meningitidis, but only …

Background Two-partner secretion systems in Gram-negative bacteria consist of an outer
membrane protein TpsB that mediates the secretion of a cognate TpsA protein into the …

Background Fulminant meningococcal sepsis with shock and multiple organ failure is
associated with a massive systemic inflammatory response involving solid organs. We have …

As with all classical monomeric autotransporters, IgA protease of Neisseria meningitidis is a
modular protein consisting of an N-terminal signal sequence, a passenger domain and a C …