The calcium‐sensing receptor (CASR) is a plasma membrane G protein coupled receptor
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …

Normal serum levels of calcium are maintained through the interplay of parathyroid, renal,
and skeletal factors. In this review, we have distinguished the neonate and infant from the …

Neonatal severe hyperparathyroidism is a rare life-threatening disorder characterized by
very high serum calcium concentrations (> 15 mg/dl). Many cases have occurred in families …

The calcium-sensing receptor (CASR) is expressed in parathyroid hormone (PTH)-secreting
cells of the parathyroid gland and cells lining the renal tubule. The activated CASR …

Abstract Calcium-sensing receptor (CASR), expressed in parathyroid gland and kidney, is a
critical regulator of extracellular calcium homeostasis. This G protein-coupled receptor exists …

The adaptor protein-2 sigma subunit (AP2σ2) is pivotal for clathrin-mediated endocytosis of
plasma membrane constituents such as the calcium-sensing receptor (CaSR). Mutations of …

Disturbances in mineral homeostasis are common in the neonatal period, especially in
premature infants and infants who are hospitalised in an intensive care unit. In many cases …

The extracellular calcium-sensing receptor (CaSR) monitors the systemic, extracellular, free
ionized-calcium level ([Ca2+] o) in organs involved in systemic [Ca2+] o homeostasis …

Familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism
(NSHPT), and autosomal dominant hypocalcemia (ADH), in which calcium homeostasis is …

Context: Neonatal severe hyperparathyroidism (NSHPT) is a severe form of familial
hypocalciuric hypercalcemia characterized by severe hypercalcemia and skeletal …