Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

The RAS genes are critical oncogenic drivers activated by point mutation in some 20% of
human malignancies. However, no pharmacologic approaches to targeting RAS proteins …

INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a
different tissue, rather than from their original tumor. After successful treatment of the original …

Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen
exposure, where they elicit rapid and robust protective immune responses,. However, the …

Using a functional model of breast cancer heterogeneity, we previously showed that clonal
sub-populations proficient at generating circulating tumour cells were not all equally capable …

It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-
HSCs) sense demand from daily and stress-mediated cues and then transition into …

Metastatic colonization relies on interactions between disseminated cancer cells and the
microenvironment in secondary organs. Here, we show that disseminated breast cancer …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia,
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …

The application of RNA interference (RNAi) to mammalian cells has provided the means to
perform phenotypic screens to determine the functions of genes. Although RNAi has …

Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of
tumor cells that have acquired endothelial-like properties. VM channels endow the tumor …