Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …

Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

Cells of the immune system and the central nervous system are capable of interacting with
each other. The former cell populations respond to infection, tissue injury and trauma by …

Background: A growing body of evidence suggests that neuroinflammation, which is
characterized by infiltration of immune cells, activation of mast cells and glial cells, and …

The inflammation process represents of a dynamic series of phenomena that manifest
themselves with an intense vascular reaction. Neuroinflammation is a reply from the central …

Rheumatic and joint diseases, as exemplified by osteoarthritis and rheumatoid arthritis, are
among the most widespread painful and disabling pathologies across the globe. Given the …

Neuropathic pain results from lesions or diseases of the somatosensory nervous system and
it remains largely difficult to treat. Peripheral neuropathic pain originates from injury to the …

Diabetic peripheral neuropathy (DPN) is a complication of diabetes connected with
morbidity and mortality. DPN presents deterioration of peripheral nerves with pain …

The presence of pain in elderly persons with cognitive decline is often neglected, under-
reported, underestimated, misdiagnosed and not adequately treated, with consequences …