Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

Significance: Wound healing is an intricate biological process in which the skin, or any other
tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of …

Angiogenesis, the process of new blood vessel formation from existing blood vessels, is a
key aspect of virtually every repair process. During wound healing an extensive, but …

Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in
malignant disease. It is an important mediator of cancer invasion, metastasis and …

Healing of cutaneous wounds is a complex and well-coordinated process requiring
cooperation among multiple cells from different lineages and delicately orchestrated …

Inflammation is a key phase in the cutaneous wound repair process. The activation of
inflammatory cells is critical for preventing infection in contaminated wounds and results in …

Significance: Proteoglycans have a distinct spatial localization in normal skin and are
essential for the correct structural development, organization, hydration, and functional …

Significance: Wound healing is a complex physiological process involving a multitude of
growth factors, among which transforming growth factor beta (TGF-β) has the broadest …

Background Cardiomyopathies are a heterogeneous group of heart diseases that can
gradually cause severe heart failure. In particular, dilated cardiomyopathy (DCM) and …

Pressure overload of the heart leads to cardiac remodeling that may progress into heart
failure, a common, morbid and mortal condition. Increased mechanistic insight into …