Malignant hyperthermia (MH) is a disorder of skeletal muscle in which certain anesthetic
agents trigger a sustained elevation in myoplasmic Ca2+ concentration that activates …

Characterising the function of genes is a major challenge in the post-genomic era. Post-
genomic tools and technologies have dramatically changed the experimental approaches …

The pale, soft, exudative (PSE) phenomenon in turkey pectoralis major (breast) muscle was
studied using a combination of biochemical, meat quality, microscopic, and gel …

To better understand the mechanisms regulating myoplasmic Ca2+ during muscle activity,
we have examined the effect of inorganic phosphate (P (i)) on the ryanodine receptor (RyR) …

Muscle growth is a complex phenomenon regulated by many factors, whereby net growth
results from the combined action of synthesis and turnover. In pigs, two quantitative trait …

Malignant hyperthermia-susceptible (MHS) pigs homozygous for the Cys615 ryanodine
receptor allele demonstrate altered sarcoplasmic reticulum (SR) ryanodine binding and …

Dantrolene inhibits and ryanodine stimulates calcium release from skeletal-muscle
sarcoplasmic reticulum (SR), the former by an unknown mechanism, and the latter by …

The cardiac muscle isoform of the ryanodine receptor/Ca 2+ release channel (RYR) has
been proposed to be an important target of cyclic ADP-ribose (cADPR) action in mammalian …

Fast-twitch and slow-twitch rat skeletal muscles produce dissimilar contractures with
caffeine. We used digital imaging microscopy to monitor Ca2+ (with fluo 3-acetoxymethyl …

The purpose of this study was to gain new insights in the role of succinylcholine in the
initiation of malignant hyperthermia (MH). The intravenous (IV) administration of …