Neuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: Synaptic transmission and …

S Battaglia, C Di Fazio, CM Vicario… - International Journal of …, 2023 - mdpi.com
Learning to recognize and respond to potential threats is crucial for survival. Pavlovian
threat conditioning represents a key paradigm for investigating the neurobiological …

Enhancing precision in human neuroscience

S Nebe, M Reutter, DH Baker, J Bölte, G Domes… - Elife, 2023 - elifesciences.org
Human neuroscience has always been pushing the boundary of what is measurable. During
the last decade, concerns about statistical power and replicability–in science in general, but …

Characterizing cardiac autonomic dynamics of fear learning in humans

S Battaglia, S Orsolini, S Borgomaneri… - …, 2022 - Wiley Online Library
Understanding transient dynamics of the autonomic nervous system during fear learning
remains a critical step to translate basic research into treatment of fear‐related disorders. In …

Beyond single paradigms, pipelines, and outcomes: Embracing multiverse analyses in psychophysiology

PE Clayson - International Journal of Psychophysiology, 2024 - Elsevier
Psychophysiological research is an inherently complex undertaking due to the nature of the
data, and its analysis is characterized by many decision points that shape the final dataset …

Multiverse analyses in fear conditioning research

TB Lonsdorf, A Gerlicher, M Klingelhöfer-Jens… - … Research and Therapy, 2022 - Elsevier
There is heterogeneity in and a lack of consensus on the preferred statistical analyses in
light of a multitude of potentially equally justifiable approaches. Here, we introduce …

Robust group-but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

M Klingelhöfer-Jens, MR Ehlers, M Kuhn, V Keyaniyan… - Elife, 2022 - elifesciences.org
Here, we follow the call to target measurement reliability as a key prerequisite for individual-
level predictions in translational neuroscience by investigating (1) longitudinal reliability at …

[HTML][HTML] Leveraging occasional reinforced extinction via mental imagery of the unconditioned stimulus to optimize extinction learning

D Scheuermann, CA Melzig, C Benke - Behaviour Research and Therapy, 2024 - Elsevier
Occasionally presenting the unconditioned stimulus (US) during extinction training
(occasional reinforced extinction, ORE) either unpaired or paired with the conditioned …

[HTML][HTML] Using electrodermal activity to estimate fear learning differences in anxiety: A multiverse analysis

MD Greaves, KL Felmingham, LJ Ney… - … Research and Therapy, 2024 - Elsevier
Meta-analyses indicate differences in Pavlovian fear responses between anxious and non-
anxious individuals using electrodermal activity (EDA). Recent research, however, has cast …

Multiverse analyses of fear acquisition and extinction retention in posttraumatic stress disorder

MW Lewis, DE Bradford, EF Pace‐Schott… - …, 2023 - Wiley Online Library
Persistent fear is a cardinal feature of posttraumatic stress disorder (PTSD), and deficient
fear extinction retention is a proposed illness mechanism and target of exposure‐based …

Quantification choices for individual differences: An example of mapping self-report to psychophysiological responses

J Morriss, N Biagi, S Wake - International Journal of Psychophysiology, 2024 - Elsevier
A popular focus in affective neuroscience research has been to map the relationships
between individual differences (eg personality and environmental experiences) and …