Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL

T Hevonoja, MO Pentikäinen, MT Hyvönen… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and
their physiological function is to carry cholesterol to the cells. In the process of atherogenesis …

Role of monocytes in atherogenesis

B Østerud, E Bjørklid - Physiological reviews, 2003 - journals.physiology.org
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …

Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis

G Camejo, E Hurt-Camejo, O Wiklund, G Bondjers - Atherosclerosis, 1998 - Elsevier
Retention of apo B-100 lipoproteins, low density lipoprotein (LDL) and probably lipoprotein
(a), Lp (a), by intima proteoglycans (PGs) appears to increase the residence time needed for …

Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes

E Leinonen, E Hurt-Camejo, O Wiklund, LM Hultén… - Atherosclerosis, 2003 - Elsevier
Objective: To investigate the relationship of inflammation and endothelial activation with
insulin resistance and adiposity in type 2 diabetes. Methods and results: Hundred and thirty …

Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH: implications for atherosclerotic …

SL Schissel, X Jiang, J Tweedie-Hardman… - Journal of Biological …, 1998 - ASBMB
The subendothelial aggregation and retention of low density lipoprotein (LDL) are key
events in atherogenesis, but the mechanisms in vivo are not known. Previous studies have …

Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions

K Öörni, MO Pentikäinen, M Ala-Korpela… - Journal of lipid …, 2000 - ASBMB
Initiation of atherosclerosis is characterized by accumulation of aggregates of small lipid
droplets and vesicles in the extracellular matrix of the arterial intima. The droplets and …

Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions

T Häkkinen, JS Luoma, MO Hiltunen… - … , and vascular biology, 1999 - Am Heart Assoc
We studied the expression of lipoprotein-associated phospholipase A2 (Lp-PLA2), an
enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and …

Modified LDL–trigger of atherosclerosis and inflammation in the arterial intima

MO Pentikäinen, K Öörni… - Journal of internal …, 2000 - Wiley Online Library
Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki,
Finland). Modified LDL–trigger of atherosclerosis and inflammation in the arterial intima …

Carboxyl ester lipase

DY Hui, PN Howles - Journal of lipid research, 2002 - ASBMB
Carboxyl ester lipase (C33347), previously named cholesterol esterase or bile salt-
stimulated (or dependent) lipase, is a lipolytic enzyme capable of hydrolyzing cholesteryl …

Circulating Levels of Secretory Type II Phospholipase A2 Predict Coronary Events in Patients with Coronary Artery Disease

K Kugiyama, Y Ota, K Takazoe, Y Moriyama… - Circulation, 1999 - Am Heart Assoc
Background—The circulating levels of secretory nonpancreatic type II phospholipase A2
(sPLA2) are increased in various chronic inflammatory diseases and the increase in the …