[HTML][HTML] SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines
The highly transmissible Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron
L Wang, M Møhlenberg, P Wang, H Zhou - Cytokine & growth factor …, 2023 - Elsevier
Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
[HTML][HTML] Neutralization, effector function and immune imprinting of Omicron variants
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
[HTML][HTML] Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA. 1 and BA. 2 receptor-binding domains
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines
JE Bowen, YJ Park, C Stewart, JT Brown… - Science …, 2022 - science.org
Numerous safe and effective coronavirus disease 2019 vaccines have been developed
worldwide that use various delivery technologies and engineering strategies. We show here …
worldwide that use various delivery technologies and engineering strategies. We show here …
[HTML][HTML] SARS-CoV-2 Omicron BA. 5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral …
A Aggarwal, A Akerman, V Milogiannakis, MR Silva… - …, 2022 - thelancet.com
Background Genetically distinct viral variants of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of …
coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of …
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …
immune escape. It remained unclear whether the emerging variants have gradually …
[HTML][HTML] Persistent immune imprinting occurs after vaccination with the COVID-19 XBB. 1.5 mRNA booster in humans
MA Tortorici, A Addetia, AJ Seo, J Brown, K Sprouse… - Immunity, 2024 - cell.com
Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
[HTML][HTML] BA. 2 and BA. 5 omicron differ immunologically from both BA. 1 omicron and pre-omicron variants
Several studies have shown that SARS-CoV-2 BA. 1 omicron is an immune escape variant.
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …