One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …

Ribosomopathies are a diverse subset of diseases caused by reduced expression of, or
mutations in, factors necessary for making ribosomes, the protein translation machinery in …

The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved
in the biogenesis of ribosomes, essential macromolecular machines responsible for …

The structure of the human ribosomal DNA (rDNA) cluster has traditionally been hard to
analyze owing to its highly repetitive nature. However, the recent development of long-read …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …

The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genomic sites
including the silent mating-type loci, telomeres, and the ribosomal DNA (rDNA) tandem …

Candida auris is a worrisome fungal pathogen of humans which emerged merely about a
decade ago. Ever since then the scientific community worked hard to understand clinically …

Heterochromatin suppresses repetitive DNA, and a loss of heterochromatin has been
observed in aged cells of several species, including humans and Drosophila. Males often …