Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications

L Yan, M Vaghari-Tabari, F Malakoti… - Critical reviews in …, 2023 - Taylor & Francis
Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling …

SA Almatroodi, MA Alsahli, A Almatroudi, AK Verma… - Molecules, 2021 - mdpi.com
Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer

M Alam, S Alam, A Shamsi, M Adnan… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …

Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer

N Oršolić, M Jazvinšćak Jembrek - International journal of molecular …, 2022 - mdpi.com
In recent years, interest in natural products such as alternative sources of pharmaceuticals
for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural …

Pharmacological aspects of natural quercetin in rheumatoid arthritis

M Tang, Y Zeng, W Peng, X Xie, Y Yang… - Drug Design …, 2023 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to severe joint
damage, disability and mortality. Quercetin (QUE) is a natural flavonoid that is ubiquitous in …

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

J Li, K Chen, X Li, X Zhang, L Zhang, Q Yang… - Cell Death …, 2023 - nature.com
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …

Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Z Long, W Xiang, Q He, W Xiao, H Wei, H Li… - Frontiers in …, 2023 - frontiersin.org
Objective To evaluate safety and efficacy of dietary polyphenols in the treatment of
rheumatoid arthritis (RA). Methods CNKI, Pubmed, Cochrane library, Embase were …

[HTML][HTML] Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus

FQ Yang, P Tang, TH Gao, CX Yang, L Tan… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus comprises a group of heterogeneous disorders, which are usually
subdivided into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Both …

Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression

GR Chai, S Liu, HW Yang, XL Chen - Neural Regeneration …, 2021 - journals.lww.com
Quercetin is a widely-occurring flavonoid that protects against cancer, and improves memory
and cardiovascular functions. However, whether quercetin exhibits therapeutic effects in …

Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review

AI Dănilă, LA Ghenciu, ER Stoicescu, SL Bolintineanu… - Biomedicines, 2024 - mdpi.com
The escalating global prevalence of diabetes mellitus (DM) over the past two decades has
led to a persistent high incidence of diabetic retinopathy (DR), necessitating screening for …