For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Abstract The voltage-gated Kv1. 3 channel and the Ca 2+-activated IKCa1 K+ channel are
expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation …

Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a
compensatory mechanism of the ubiquitin-proteasome system. p62/SQSTM1 is a key …

Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but
it is not known how the autophagic machinery recognizes such aggregates. In this study, we …

Herein, we demonstrate that the ubiquitin-associated (UBA) domain of sequestosome 1/p62
displays a preference for binding K63-polyubiquitinated substrates. Furthermore, the UBA …

To counteract fluctuating nutrient environments, plants have evolved high‐and low‐affinity
uptake systems. These two systems were traditionally thought to be genetically distinct, but …

The Phox and Bem1p (PB1) domain constitutes a recently recognized protein-protein
interaction domain found in the atypical protein kinase C (aPKC) isoenzymes, λ/ι-and ζPKC; …

The atypical protein kinase C (aPKC)‐interacting protein, p62, has previously been shown to
interact with RIP, linking these kinases to NF‐κB activation by tumor necrosis factor α …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The formation of Lewy bodies (LBs) and their relationship to other types of nigral inclusions
associated with Parkinson disease (PD), such as pale bodies (PBs), remain poorly …