Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …

Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their
distribution and function in tissues remains largely unknown. Here, we present a unique …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Background—Inappropriately sustained inflammation is a hallmark of chronic ischemic heart
failure (HF); however, the pathophysiological role of T lymphocytes is unclear. Methods and …

Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of
antigen presented by dendritic cells,. Once activated, they proliferate vigorously, generating …

As acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptor lo
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …

The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …

The proper function of immune surveillance requires well-coordinated mechanisms in order
to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid …