Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …

Autoimmune diseases are typically studied with a focus on the immune system, and less
attention is paid to responses of target tissues exposed to the immune assault. We presently …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown.
While autoantibodies to pancreatic beta-cell antigens are often the first biological response …

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune
tolerance to the body's own cells and tissues. There is growing recognition that RNA …

Type 1 diabetes (T1D) is a chronic disease caused by the selective destruction of the insulin-
producing pancreatic beta cells by infiltrating immune cells. We presently evaluated the …

Background It has been reported that diabetes mellitus affects 435 million people globally as
a primary health care problem. Despite many therapies available, many diabetes remains …

Background The presence and significance of neural remodeling in premature ventricular
contraction-induced cardiomyopathy (PVC-CM) remain unknown. Objectives This study …