Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …

Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

Notch signalling is a cell–cell communication process, which allows the establishment of
patterns of gene expression and differentiation, regulates binary cell fate choice and the …

Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand
binding induces metalloprotease cleavage of Notch within an extracellular negative …

Abstract The chromosomal translocation t (7; 9) in human T-cell acute lymphoblastic
leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch …

From its beginnings two decades ago with the analysis of chromosomal translocation
breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia …