The unprecedented rise in life expectancy observed in the last decades is leading to a
global increase in the ageing population, and age-associated diseases became an …

Alzheimer's disease (AD) is the most frequent form of dementia. It is characterized by
pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition …

Cardiovascular diseases are the leading cause of death globally. Within cardiovascular
aging, arterial aging holds significant importance, as it involves structural and functional …

Age is the number one risk factor for developing a neurodegenerative disease (ND), such as
Alzheimer's disease (AD) or Parkinson's disease (PD). With our rapidly ageing world …

Every 25th death worldwide is associated with liver pathology. The development of novel
approaches to liver diseases therapy and protocols for maintaining the vital functions of …

Background Dental pulp stem cells (DPSCs) possess mesenchymal stem cell characteristics
and have potential for cell-based therapy. Cell expansion is essential to achieve sufficient …

Studying adipogenesis and adipocyte biology requires the isolation of primary
preadipocytes from adipose tissues. However, primary preadipocytes have a limited …

Most mammalian genes undergo alternative splicing. The splicing of some exons has been
acquired or lost in specific mammalian lineages, but differences in splicing within the human …

Methods and Results Here we found that physioxia (3% O 2) compared to normoxia (21% O
2) increased proliferation, maintained stemness by suppression of spontaneous …

A major challenge in aging research is identifying interventions that can improve lifespan
and health and minimize toxicity. Clinical studies cannot consider decades-long follow-up …