Systematic review of Gossypol/AT-101 in cancer clinical trials
O Renner, M Mayer, C Leischner, M Burkard, A Berger… - Pharmaceuticals, 2022 - mdpi.com
The potential of gossypol and of its R-(−)-enantiomer (R-(−)-gossypol acetic acid, AT-101),
has been evaluated for treatment of cancer as an independent agent and in combination …
has been evaluated for treatment of cancer as an independent agent and in combination …
Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors
Deregulated apoptosis is a hallmark of cancer, and the B-cell lymphoma-2 (Bcl-2) family of
proteins is pivotal to mediating the intrinsic pathway of this process. Recent advances have …
proteins is pivotal to mediating the intrinsic pathway of this process. Recent advances have …
Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype
Emerging evidence suggests that endothelial cell-secreted factors contribute to the
pathobiology of squamous cell carcinoma (SCC) by enhancing invasive migration and …
pathobiology of squamous cell carcinoma (SCC) by enhancing invasive migration and …
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma
S Song, Q Chen, Y Li, G Lei, A Scott, L Huo, CY Li… - Gut, 2021 - gut.bmj.com
Objective Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor
prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy …
prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy …
A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer
Background: AT-101 is a BCL-2 Homolog domain 3 mimetic previously demonstrated to
have tumoricidal effects in advanced solid organ malignancies. Given the evidence of …
have tumoricidal effects in advanced solid organ malignancies. Given the evidence of …
A validated mathematical model of FGFR3‐mediated tumor growth reveals pathways to harness the benefits of combination targeted therapy and immunotherapy in …
K Okuneye, D Bergman, JC Bloodworth… - Computational and …, 2021 - Wiley Online Library
Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly
18,000 deaths per year in the United States alone. Therapeutic options for metastatic …
18,000 deaths per year in the United States alone. Therapeutic options for metastatic …
Development of Degradable, pH‐Sensitive Star Vectors for Enhancing the Cytoplasmic Delivery of Nucleic Acids
YY Durmaz, YL Lin… - Advanced Functional …, 2013 - Wiley Online Library
The report describes the synthesis of degradable, pH‐sensitive, membrane‐destabilizing,
star‐shaped polymers where copolymers of hydrophobic hexyl methacrylate (HMA) and 2 …
star‐shaped polymers where copolymers of hydrophobic hexyl methacrylate (HMA) and 2 …
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non …
T Ren, J Shan, M Li, Y Qing, C Qian… - Drug design …, 2015 - Taylor & Francis
AT-101 is a BH3 mimetic and pan-Bcl-2 inhibitor that has shown potent anticancer activity in
non-small-cell lung cancer (NSCLC) in murine models, but failed to show clinical efficacy …
non-small-cell lung cancer (NSCLC) in murine models, but failed to show clinical efficacy …
(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c …
M Benvenuto, R Mattera, L Masuelli… - … journal of food …, 2017 - Taylor & Francis
Abstract Racemic Gossypol [(±)-GOS], composed of both (−)-GOS and (+)-GOS, is a small
BH3-mimetic polyphenol derived from cotton seeds.(±)-GOS has been employed and well …
BH3-mimetic polyphenol derived from cotton seeds.(±)-GOS has been employed and well …
Head and neck cancer: metronomic chemotherapy
F De Felice, D Musio, V Tombolini - BMC cancer, 2015 - Springer
In the era of personalized medicine, head and neck squamous cell carcinoma (HNSCC)
represents a critical oncologic topic. Conventional chemotherapy regimens consist of drugs …
represents a critical oncologic topic. Conventional chemotherapy regimens consist of drugs …