Transcription directionality is licensed by Integrator at active human promoters
J Yang, J Li, L Miao, X Gao, W Sun, S Linghu… - Nature Structural & …, 2024 - nature.com
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA
polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable …
polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable …
Structural basis of Integrator-dependent RNA polymerase II termination
The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …
region of genes. Previous work has shed light on how Integrator binds to the paused …
Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function
INTS11 and CPSF73 are metal-dependent endonucleases for Integrator and pre-mRNA 3′-
end processing, respectively. Here, we show that the INTS11 binding partner …
end processing, respectively. Here, we show that the INTS11 binding partner …
The enhancer module of Integrator controls cell identity and early neural fate commitment
Lineage-specific transcription factors operate as master orchestrators of developmental
processes by activating select cis-regulatory enhancers and proximal promoters. Direct DNA …
processes by activating select cis-regulatory enhancers and proximal promoters. Direct DNA …
Catalytic-independent functions of the Integrator–PP2A complex (INTAC) confer sensitivity to BET inhibition
P Fan, XY Shang, A Song, S Chen, RY Mao… - Nature Chemical …, 2025 - nature.com
Chromatin and transcription regulators are critical to defining cell identity through shaping
epigenetic and transcriptional landscapes, with their misregulation being closely linked to …
epigenetic and transcriptional landscapes, with their misregulation being closely linked to …
Structure of the human 20S U5 snRNP
S Schneider, I Brandina, D Peter, S Lagad… - Nature Structural & …, 2024 - nature.com
The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein
complex and a precursor of the U4/U6. U5 tri-snRNP, the major building block of the …
complex and a precursor of the U4/U6. U5 tri-snRNP, the major building block of the …
Basis of gene-specific transcription regulation by the Integrator complex
The Integrator complex attenuates gene expression via the premature termination of RNA
polymerase II (RNAP2) at promoter-proximal pausing sites. It is required for stimulus …
polymerase II (RNAP2) at promoter-proximal pausing sites. It is required for stimulus …
Structural basis of 5′ splice site recognition by the minor spliceosome
J Zhao, D Peter, I Brandina, X Liu, WP Galej - Molecular Cell, 2025 - cell.com
The minor spliceosome catalyzes excision of U12-dependent introns from precursors of
eukaryotic messenger RNAs (pre-mRNAs). This process is critical for many cellular …
eukaryotic messenger RNAs (pre-mRNAs). This process is critical for many cellular …
Structural basis of the Integrator complex assembly and association with transcription factors
M Razew, A Fraudeau, MM Pfleiderer, R Linares… - Molecular Cell, 2024 - cell.com
Integrator is a multi-subunit protein complex responsible for premature transcription
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
Unprocessed snRNAs Are a Prognostic Biomarker and Correlate with a Poorer Prognosis in Colorectal Cancer
V Escrich, C Romero-Aranda, R López, M de Toro… - Cancers, 2024 - mdpi.com
Simple Summary Integrator-complex deregulation is involved in 8.3% of colorectal cancer
cases. Lack of Integrator-complex function, measured by an increased level of unprocessed …
cases. Lack of Integrator-complex function, measured by an increased level of unprocessed …